Author

Year

No. of patients

Design

Test used

Main outcome

Almohmmed A [26]

Heart 1998

27

Observational

PET

52% of viability suitable for revascularization

Auerbach MA [27]

Circulation 1999

283

Observational

PET

55% of viability, 27% improved with revasculrization

Schinkel AFL [28]

Heart 2002

104

A retrospective observational study

SPECT

61% of viability improved with revasculrization

Schinkel AFL [29]

Am J Cardiol 2001

150

Observational

DSE

37% of viability improved with revasculrization

Bonow RO [17]

N Engl J Med 2011 (Stich)

601

Randomized controlled trial

DSE and SPECT

No significant interaction between viability status and treatment assignment with respect to mortality

Beanlands RS [23]

Am J Cardiol 2007 (PARR-2)

218

Randomized controlled trial

PET

Did not demonstrate a significant reduction in cardiac events in patients with LV dysfunction and coronary disease for FDG PET-assisted management versus standard care

Cleland JGF [25]

Eur J Heart Fail 2011 (HEART)

138

Unblinded randomized controlled

DSE and NUCLEAR

There were no differences in mortality by intention-to-treat with use of viability testing

Stipac AV [30]

Heart 2013

115

Prospective observational cohort study.

DSE

It appears that patients with LV dysfunction, but without viable myocardium, may also benefit from myocardial revascularisation.

Shah DJ [31]

JAMA 2013

1055

Observational prospective

MRI

Among patients with CAD referred for CMR and found to have regional wall thinning, limited scar burden was present in 18% and was associated with improved contractility and resolution of wall thinning after revascularization